A nonsense mutation in PRNP associated with clinical Alzheimer's disease☆

نویسندگان

  • Rita Guerreiro
  • José Brás
  • Aleksandra Wojtas
  • Rosa Rademakers
  • John Hardy
  • Neill Graff-Radford
چکیده

Here, we describe a nonsense haplotype in PRNP associated with clinical Alzheimer's disease. The patient presented an early-onset of cognitive decline with memory loss as the primary cognitive problem. Whole-exome sequencing revealed a nonsense mutation in PRNP (NM_000311, c.C478T; p.Q160*; rs80356711) associated with homozygosity for the V allele at position 129 of the protein, further highlighting how very similar genotypes in PRNP result in strikingly different phenotypes.

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عنوان ژورنال:

دوره 35  شماره 

صفحات  -

تاریخ انتشار 2014